Bimatoprost was introduced in the market fundamentally for the treatment for glaucoma. The brand name of this product is careprost or bimat. The history of Bimatoprost goes something like this. Patients of glaucoma who were using this medicine observed that their eyelashes were getting longer. This side effect of careprost got incorporated in eyelash growth treatment. Careprost is generally considered to be a part of prostaglandin family of ocular hypotensive analogues. Studies endorsed by the manufacturer, nevertheless, imply that Bimat differs significantly in both structure as well as function when it is compared to other prostaglandin compounds to warrant a new class of ocular hypotensive agents, called prostamides. Prostamides are members of the fatty acid amide family. Careprost is an artificial analogue that mimics the actions of prostamides, effectively alleviating the intraocular pressure. It comes as an ophthalmic solution in the concentration of 0.01% or 0.03%.
Mechanism Of Action Bimatoprost Ophthalmic Solution 0.03
As far as the mechanism of action is concerned, Bimatoprost helps in reducing intraocular pressure in glaucoma patients by acting on prostamide-sensitive receptors. Pharmaceutical studies have shown that it does not act through any known prostanoid receptor, including the Prostaglandin F receptor. More recent studies have shown that Careprost does exhibit properties of a pro drug and has a weak activity at the FP receptor. There is a considerable controversy regarding Bimat. It is also assumed that Careprost increases the level of aqueous humor through the trabecular-mesh work outflow pathway. Studies have also made it clear that 50% increase in uveoscleral outflow is caused by it. Hence, the ocular hypotensive action of bimat is believed to be due to a dual mechanism of increasing aqueous outflow through both the pressure sensitive trabecular and pressure insensitive uveoscleral pathways. Onset of action to reduce intraocular pressure is around 4 hours after first administration. The effect lasts for around 8 to 12 hours.
Bimat increases the length of the eyelashes by increasing the percent of hair, and the duration of manage or growth phase.
How to Use Bimatoprost?
i. For glaucoma
1 drop (get) in the eye(s) one time daily in evening should be administered. The dosage should not be exceeded. More frequent usage may reduce its effect of reducing the intraocular pressure. If other drugs are used to lower the intraocular pressure, administer them at least for nearly five minutes apart. Dropper should be used. The tip of the dropper should not touch any other surface so that there is no risk of contamination. Tilt the head back slightly and pull the lower eyelid down with the index finger to form a pouch. Gently close the eyes for 1-2 minutes after instilling the drops. Do not blink.
II. For eyelash enhancement
When Bimat is used for hypotrichosis of the eyelashes, it should be used once every night for around two to three months. Place one drop of the solution on the disposable sterile applicator provided with the package. Utilize in a also approach over the epidermis on the upper eyelid border with the starting on the eyelashes. Use the same method for the opposite eyelid margin using a new sterile applicator. The lower eyelash line should not be included in this procedure. Use after removal of makeup. Also, wash the face properly before using it. Eyelashes have an important aesthetic appeal these days and long eyelashes are a mark of glamour. That’s the reason why Careprost has gained significant popularity as an eyelash enhancer.
Rejuvenation of the periorbital area of patients is also a desirable effect of Bimat.
Precautions to Be Taken While Using Bimatoprost
• It should be stored in the original container at 15-25 degree Celsius. Do not freeze.
• Excess solution should be blotted with a tissue or other absorbent cloth if it is used for eyelash lengthening.
• Eyes should be evaluated for inflammation, exudates, pain, vision level and color of iris.
• Liver function tests should be monitored.
• Lenses should be removed prior to its usage.
• Until vision clears, no hazardous functions should be performed.
• Patients who are at risk of uveitis or macular edema should refrain from using Careprost.
Contraindications and Side Effects of Careprost
1 Careprost is not been assessed for treating of angle closure or neovascular glaucoma.
2 Inflammatory Patients of open angle glaucoma cannot be treated with it.
3 Permanent changes in the iris and darkening of eyelid skin can be noticed.
4 If the product is contaminated, bacterial keratitis is possible.
5 Lactating women should not use this formulation.
6 Conjunctival hyperemia has been reported as an adverse effect of the treatment with an incidence of 3.6%
User Reviews of Buy Bimatoprost Online
Short eyelashes posed a major problem for me. I had tried many ordinary cosmetic products to get longer eyelashes but none of them worked. I had given up on that hope of having charming eyelashes until my boyfriend gifted me Bimat. He had researched the medication well, just for me. I started using it as per his directions. In eight weeks, I got beautiful eyelashes like I craved for. If you too wish to have more prominent eyelashes, you can certainly use Bimat. Bimatoprost for sale is available on online pharmacy stores. You can place an order and you would soon receive it at your doorstep without any complicated procedure. No prescription is required to buy Bimat product. All ophthalmic solutions are liable to get absorbed in the systemic circulation and cause some level of systemic toxicity. However, Careprost hardly had any systemic adverse effects. I could not properly curl my eyelashes or apply mascara over it because of its short length. Today, I can beautify my eyelashes as per my will, without any worries because of the lash growth serum bimatoprost online.